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    What can you expect from the 4th Medicial Clinic Targu Mures, Romania ?

    The 4th Medicial Clinic Targu Mures, Romania, is a research intensive academic institution with busy in- and outpatient departements focused on cardiology and internal medecine. Our medical, research and administrative staff offer the expertise needed to make clinical trials a success for sponsors and patients. We are experienced in phase II-IV international clinical trials and we are looking for partners interested in research cooperation.

    Main therapeutic areas / diagnostic facilities:

  • Coronary artery disease / stress test / coronarography
  • Heart failure / echocardiography
  • Hypertension / 24 h ABPM
  • Syncope / tilt testing
  • Arrhythmias / Holter ECG, electrophysiological study
  • Peripheral vascular diseases / Doppler



  • Beside our own research themes, we participated in the following international trials:


    AMISTAD
  • Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of Adenosine (AMISTAD) trial.
  • Mahaffey KW, Puma JA, Barbagelata NA, DiCarli MF, Leesar MA, Browne KF, Eisenberg PR, Bolli R, Casas AC, Molina-Viamonte V, Orlandi C, Blevins R, Gibbons RJ, Califf RM, Granger CB
  • J Am Coll Cardiol. 1999 Nov 15;34(6):1711-20



  • EPHESUS (ongoing)
  • The EPHESUS trial: eplerenone in patients with heart failure due to systolic dysfunction complicating acute myocardial infarction. Eplerenone Post-AMI Heart Failure Efficacy and Survival Study.
  • Pitt B, Williams G, Remme W, Martinez F, Lopez-Sendon J, Zannad F, Neaton J, Roniker B, Hurley S, Burns D, Bittman R, Kleiman J
  • Cardiovasc Drugs Ther. 2001 Jan;15(1):79-87


    SENIORS
  • Study of the Effects of Nebivolol Intervention on Outcomes and Rehospitalisation in Seniors with Heart Failure (SENIORS). Rationale and design.
  • Shibata MC, Flather MD, Bohm M, Borbola J, Cohen-Solal A, Dumitrascu D, Ferrari R, Lechat P, Parkhomenko A, Soler-Soler J, Tavazzi L, Toman J, Van Veldhuisen DJ, Coats AJ, Poole-Wilson P; Study of the Effects of Nebivolol Intervention on Outcomes and Rehospitalisation in Seniors with Heart Failure.
  • Int J Cardiol. 2002 Nov;86(1):77-85


    PREVENT

  • Rationale and design of a clinical trial of a low-molecular-weight heparin in preventing clinically important venous thromboembolism in medical patients: the prospective evaluation of dalteparin efficacy for prevention of venous thromboembolism in immobilized patients trial (the PREVENT study).
  • Vaitkus PT, Leizorovicz A, Goldhaber SZ; PREVENT Investigator Group.
  • Vasc Med. 2002;7(4):269-73
  • The 4th Medical Clinic and its outpatient departement is affiliated to the County Emergency Hospital and to the University of Medicine and Pharmacy Targu Mures, being located in the University campus.
    ________________________________________
    For more information please contact:

    Cristian Podoleanu MD, PhD
    Specialist in cardiology and internal medicine Assistant Professor
    Cardiology Department - 4th Medical Clinic
    University Clinic Hospital Targu Mures
    Romania
    emailadres: pcristi@gmx.de